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Ameela Exosomes

Ameela Exosomes deliver a multi-phase regenerative complex combining

plant-derived exosomes, Wild Salmon PDRN, Bio-Mimetic Growth Factors,

Hexapeptide-8 and Ameela Collagen. This advanced formulation calms inflammation (TNF-α, IL-6), activates angiogenesis and DNA repair via A2A receptors, stimulates fibroblast-driven ECM renewal, modulates expression lines and reinforces dermal architecture - optimising skin recovery,

resilience and visible rejuvenation.

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Product Specifications

Stimulates collagen and angiogenesis.
Reduces inflammation and oxidative stress.
Enhances barrier repair and hydration.
Softens dynamic wrinkles.
Improves skin tone, elasticity and post-procedure recovery.

Ameela Precision Regeneration in One Syringe - A Complete Cellular Reset

1. Initiation Phase: Cellular Priming & Inflammation Reset

Grapefruit & Watermelon Exosomes deliver antioxidant-rich plant mRNA and lipid mediators directly into skin cells. They modulate cellular communication, reduce oxidative stress and reset inflammatory pathways (TNF-α, IL-6), preparing the skin for deep regeneration.

2. Activation Phase: DNA Repair & Tissue Regeneration

PDRN binds to A2A receptors initiating: Angiogenesis (via VEGF upregulation), Fibroblast activation, ECM synthesis and cellular turnover. Act like a healing signal, accelerating skin repair at the molecular level whilst stimulating collagen and microvascular renewal.

3. Growth Factor Phase: Mimicking the Skin’s Youth Code

Ameela Growth Factor Complex mimics five key human GF’s: EGF for epidermal renewal, IGF-1 for cellular metabolism & repair, bFGF for fibroblast proliferation & collagen I/III production, VEGF for microcirculation & nutrient delivery and TGF-β for matrix remodelling & inflammation control. Together, these factors create a controlled wound-healing cascade – boosting collagen, elastin and hydration.

4. Modulation Phase: Wrinkle Relaxation & Expression Softening

Hexapeptide-8 mimics botulinum toxin’s mechanism by gently interrupting the SNARE complex formation to reduce dynamic wrinkles. Smooths facial tension without freezing expression, offering refined muscle modulation.

5. Integration Phase: Structural Support & Barrier Fortification

Ameela Collagen restores dermal density, water retention and ECM stability. Acts as a 3D scaffolding system for all the actives - holding hydration, anchoring peptides and amplifying growth factor effects. It is the finishing architecture locking in results and creating long-term skin integrity.

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PDRN + Hexapeptide-8 (Argireline®)

Wild Salmon-Derived Ameela Polynucleotides: Extracted from wild salmon DNA, ensuring pharmaceutical-grade purity, optimal bioavailability and minimal immunogenicity.
A2A Receptor Activation: Low molecular weight enables deep skin penetration and direct binding to adenosine A2A receptors - stimulating angiogenesis, fibroblast activity and ECM renewal via VEGF and TGF-β pathways.
Immunomodulatory Effect: Downregulates pro-inflammatory cytokines, aiding in resolution of inflammation and oxidative stress.
Softens Expression Lines: Hexapeptide-8 inhibits SNARE-mediated neurotransmission, visibly reducing expression lines through targeted muscle relaxation.

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Ameela Collagen

Targeted Collagen Support: Bioengineered to stimulate collagen synthesis, ECM renewal and structural preservation at the cellular level.
Clinically Validated: Demonstrated 66% increase in Pro-Collagen I, 62% rise in SPARC and 37% MMP1 reduction – supporting Collagen regeneration and anti-degradation.
UV Stress Protection: Ex vivo studies show 50% reduction in UVA-induced collagen damage, preserving dermal integrity under environmental stress.
Clean + Sustainable: Non-GMO, free from nicotine, alkaloids and animal contaminants -safe, compliant and eco-conscious.

Growth Factors

Clinically Relevant: Bioengineered analogues of human growth factors (EGF, IGF-1, bFGF, VEGF, TGF-β) to deliver natural skin repair signalling with precision and safety.
Multi-Layer Renewal: Stimulates keratinocytes, fibroblasts and endothelial cells to boost epidermal turnover, collagen synthesis and angiogenesis.
ECM Restoration: Enhances dermal integrity by upregulating collagen I/III, elastin and fibronectin while reducing MMP activity.
Advanced Repair: Supports wound healing and cellular protection in UV-damaged or ageing skin.

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Grapefruit + Watermelon Exosomes

High-Density Delivery: Contains 40 billion plant-derived exosomes per syringe -optimised for intercellular communication and active ingredient delivery at scale.
Anti-Inflammatory Modulation: Regulates key cytokines (TNF-α, IL-6), resetting inflammation and accelerating repair.
Antioxidant-Rich Cargo: Delivers antioxidant enzymes, lipids and mRNA that neutralise ROS and protect against oxidative stress.
Biocompatible & Non-Immunogenic: Naturally derived from plant cells - safe, effective and reducing risk of immune reactivity while maintaining high biological activity.

Ameela Exosomes Clinically Proven Results

1

Reinforces Skin Barrier & Reduces Wrinkles

Clinically shown to improve skin barrier function and reduce wrinkle depth. Support hydration, structural resilience and dermal protection.

2

Stimulates Collagen Production & Elasticity

Demonstrated increases of up to 66% in Pro-Collagen I and 62% in SPARC expression, with a 37% reduction in MMP1. Promotes firmer, smoother skin by enhancing fibroblast activity and preserving the extracellular matrix.

3

Reduces Inflammation & Accelerates Recovery

Reduces UVA-induced collagen degradation by up to 50% and downregulates inflammatory markers (TNF-α, IL-6), supporting faster healing, reduced redness and improved skin tone uniformity.